![]() The sensitization rate to the product is 0.7%. PVP-I is contraindicated in people with hyperthyroidism (overactive thyroid gland) and other diseases of the thyroid, after treatment with radioiodine, and in people with dermatitis herpetiformis (Duhring's disease). There is strong evidence that chlorhexidine and denatured alcohol used to clean skin prior to surgery is better than any formulation of povidone-iodine. For this purpose, povidone-iodine is equally effective and safe as talc, and may be preferred because of easy availability and low cost. It is used in pleurodesis (fusion of the pleura because of incessant pleural effusions). PVP-I appears to be very suitable for this purpose because, unlike other substances, it is also efficient against fungi and viruses (including HIV and Herpes simplex). It is currently unclear whether PVP-I is more effective in reducing the number of cases of conjunctivitis in neonates over other methods. Eyes Ī buffered PVP-I solution of 2.5% concentration can be used for prevention of neonatal conjunctivitis, especially if it is caused by Neisseria gonorrhoeae, or Chlamydia trachomatis. All the toxic and staining effects of PVP-I is due to the inactive iodine only. Most commonly used 10% PVP-I delivers about 1–3 ppm of I2 in a compound of more than 31,600 ppm of total iodine atoms. Īntiseptic activity of PVP-I is because of free iodine (I2) and PVP-I only acts as carrier of I2 to the target cells. Since these bacteria are resistant to povidone iodine, statements that bacteria do not develop resistance to PVP-I, should be regarded with great caution: some bacteria are intrinsically resistant to a range of biocides including povidone-iodine. Its ability to harbor such microbes further underscores the importance of using sterile products in any clinical setting. Pseudomonas cepacia), and other opportunistic pathogens. The non-sterile form of Povidone iodine has a long history of intrinsic contamination with Burkholderia cepacia ( a.k.a. Non-sterile product can be appropriate in limited circumstances in which people have intact, healthy skin that will not be compromised or cut. īecause of these critical indications, only sterile povidone-iodine should be used in most cases. For these purposes PVP-I has been formulated at concentrations of 7.5–10.0% in solution, spray, surgical scrub, ointment, and swab dosage forms however, use of 10% povidone-iodine though recommended, is infrequently used, as it is poorly accepted by health care workers and is excessively slow to dry. Ĭonsequently, PVP-I has found broad application in medicine as a surgical scrub for pre- and post-operative skin cleansing for the treatment and prevention of infections in wounds, ulcers, cuts and burns for the treatment of infections in decubitus ulcers and stasis ulcers in gynecology for vaginitis associated with candidal, trichomonal or mixed infections. Chlorhexidine is almost twice as effective in preventing infection after surgery with a similar to lower risk of adverse events, and the combination of sodium hypochlorite and hypochlorous acid in very low concentration is significantly superior for wound healing. Povidone-iodine exhibits longer lasting antiseptic effects than tincture of iodine, due to its slow absorption via soft tissue, making it the choice for longer surgeries. It may be used in first aid for minor cuts, burns, abrasions and blisters. Povidone-iodine is a broad spectrum antiseptic for topical application in the treatment and prevention of wound infection. It is sold under a number of brand names including Betadine. Povidone-iodine is available over the counter. It is on the World Health Organization's List of Essential Medicines. Povidone-iodine came into commercial use in 1955. It works by releasing iodine which results in the death of a range of microorganisms. It contains 10% Povidone, with total iodine species equaling 10,000 ppm or 1% total titratable iodine. Povidone-iodine is a chemical complex of povidone, hydrogen iodide, and elemental iodine. Frequent use is not recommended in people with thyroid problems or who are taking lithium. It is not recommended in women who are less than 32 weeks pregnant. If used on large wounds, kidney problems, high blood sodium, and metabolic acidosis may occur. Side effects include skin irritation and sometimes swelling. It may be applied to the skin as a liquid or a powder. It may be used both to disinfect the hands of healthcare providers and the skin of the person they are caring for. Povidone-iodine ( PVP-I), also known as iodopovidone, is an antiseptic used for skin disinfection before and after surgery.
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